A Conversation with Geneviève Almouzni
- Senior Editor, Nature Reviews Molecular Cell Biology
This extract was created in the absence of an abstract.
Geneviève Almouzni is Director of the Chromatin Dynamics Group at the Curie Institute.
Eytan Zlotorynski:You're interested in chromatin structure and chromosome organization during the cell cycle and development, with a special interest in histone variants. Why histone variants and what is the significance of certain histone variants for chromosome organization?
Dr. Almouzni:Histone variants give variability to the basic particle, the nucleosome, by marking particular regions of the genome. The most striking example is the centromeric variant called CENP-A (centromere protein A) in mammals and CenH3 in other species, which marks the sites where the kinetochore forms, an important structure for segregating chromosomes.
Eytan Zlotorynski:What were your main findings about the roles of CENP-A and its interacting proteins in centromere formation during the cell cycle?
Dr. Almouzni:There's a very particular point during the cell cycle in late mitosis when CENP-A is deposited during the organization of the …
