tRNA Conformity
This extract was created in the absence of an abstract.
Excerpt
The 30 or more different transfer RNA moleculespresent in all cells have a similar size and overall threedimensional architecture, but differ in nucleotide sequence. Numerous enzymes are involved in the maturation, modification, biochemical function, and degradation of each individual tRNA. These include enzymesthat are specific for a small subclass of all tRNAs, such asthe aminoacyl-tRNA synthetases and certain tRNA-modifying enzymes, as well as a group of enzymes that interact with nearly all tRNAs, such as RNase P, rT54 methylase, elongation factor Tu (EF-Tu), and the ribosome. Achallenge for biochemists is to understand how this set ofstructurally similar RNA molecules can be substrates forboth specific and nonspecific enzymes...
