Structural Studies of Human TRAF2
This extract was created in the absence of an abstract.
Excerpt
The tumor necrosis factor (TNF) receptor (TNFR) superfamily effects a wide spectrum of cellular responses including proliferation, differentiation, and apoptosis (for review,see Smith et al. 1994). Current members of TNFRs includeTNF-R1, TNF-R2, Fas, CD40, CD30, CD27, LTβR, Ox40,4-1BB, RANK, p75 nerve growth factor (NGF) receptor,and a series of death receptors (DRs). Recent studies haveimplicated the TNFR-associated factors (TRAFs) as majorsignal transducers for many members of this receptor superfamily (for review, see Arch et al. 1998). The Epstein-Barr virus (EBV) oncogene product LMP1 also usesTRAFs for inducing long-term growth potentiation and celltransformation (Mosialos et al. 1995). In addition, TRAFsignaling is important for receptors of the pro-inflammatorycytokine interleukin-1 (IL-1) (Cao et al. 1996b). The downstream signaling of TRAFs appears to involve the activation of kinases in the MAPK family, leading eventually tothe activation of Rel (NF-κB) and AP-1 transcription factors (for review, see Arch et al. 1998). These transcriptionfactors can switch on various genes involved in inflammatory, immune, and acute phase responses...
