Cell Membrane Molecule I-J Transduces a Negative Signal for Early T-cell Activation Induced via the TCR
This extract was created in the absence of an abstract.
Excerpt
I-J was first described as a marker of T-suppressor cells (Ts) and suppressor factors (TsF) controlled by a gene of the mouse major histocompatibility complex (MHC) (Murphy et al. 1976; Tada et al. 1976; for review, see Murphy 1987). Several T-cell hybridomas expressing I-J or producing the I-J-bearing TsF were produced, and a number of monoclonal anti-I-J antibodies were established in several laboratories (Kanno et al. 1981; Waltenbaugh 1981; Kurata et al. 1984). Subsequent studies have, however, revealed that the I-J gene could not be encoded within the MHC by molecular cloning analyses (Steimetz et al. 1982; Kobori et al. 1984, 1986) and that the I-J transcript was not detected in T-cell hybridomas expressing I-J on their surface by cosmid probes covering the whole stretch of I region of MHC (Kronenberg et al. 1982). The compelling evidence thus indicated that I-J is not a direct product of an MHC gene...
