Transcriptional Regulation of c-fos
- R. Prywes,
- T.M. Fisch, and
- R.G. Roeder
This extract was created in the absence of an abstract.
Excerpt
Expression of the c-fos proto-oncogene is induced rapidly and transiently by serum and other mitogenic agents (Greenberg and Ziff 1984; Kruijer et al. 1984; Muller et al. 1984). Induction is at the level of transcription and can be observed within 5 minutes of treatment with serum. This transcriptional activation peaks after 15 minutes and subsequently decreases to basal levels within 2 hours. Induction occurs in the presence of cycloheximide, demonstrating that new protein synthesis is not involved (Cochran et al. 1984; Kruijer et al. 1984; Muller et al. 1984; Greenberg et al. 1986). This rapid induction is therefore likely to involve posttranslational modifications and provides an excellent model for an early nuclear target of the signal transduction process. Growth factors that bind to tyrosine kinase receptors (epidermal growth factor [EGF], platelet-derived growth factor [PDGF]), activators of protein kinase C (12-O-tetradecanoyl phorbol-13-acetate [TPA]), calcium ionophore, and cAMP all activate c-fos transcription...
