Human fos Gene
This extract was created in the absence of an abstract.
Excerpt
A decade ago it was observed that the transforming gene src of avian sarcoma virus has counterparts in normal chicken chromosomal DNA (Stehlin et al. 1976). Since then src-specific sequences have been detected across all species, from Homo sapiens to yeast (Varmus 1982; Bishop 1983; Weinberg 1983; Hunter 1984). This realization that normal cells harbor genes that have the potential to induce neoplasia was a turning point in modern cancer research. Such genes, collectively called oncogenes or proto-oncogenes, were first discovered through the agency of retroviruses, a group of viruses that cause tumors in experimental animals (Cooper 1982). Since human neoplasias generally do not display viral etiology (human acute T-cell leukemia and AIDS being recent exceptions), the appearance of oncogenes on the tumor biology scene was not greeted with overt enthusiasm.
Through an entirely different route of experiments carried out by a number of investigators, it was shown that transfection...
