Molecular Genetic Analysis Reveals Chromosomal Deletion, Gene Amplification, and Autocrine Growth Factor Production in the Pathogenesis of Human Lung Cancer
This extract was created in the absence of an abstract.
Excerpt
Lung cancer is a major health problem in the United States with over 140,000 new cases expected in 1986; 90% of these persons will die of their disease within 1 year of diagnosis (Minna et al. 1985; Bailar and Smith 1986). Despite antismoking campaigns and many treatment studies, the mortality rate from lung cancer is rising dramatically for both men and women to a level of over 50 persons per 100,000 population per year, while the rates for other common malignancies are stable (breast cancer) or falling slightly (colo-rectal cancer) to levels of 20 persons per 100,000 population per year (Bailar and Smith 1986). Clearly, new, more effective measures to prevent or cure lung cancer are needed to change the overall mortality rate of cancer in the United States.
There are four major histologic types of lung cancer: squamous or epidermoid carcinoma (representing 25%), adenocarcinoma (30%), large cell carcinoma (15%),...
