Mechanisms of Receptor-mediated Transmembrane Communication
This extract was created in the absence of an abstract.
Excerpt
All cells are delimited by a plasma membrane, which constitutes a permeability barrier between the intracellular compartment and the extracellular milieu. Thus, the ability of such cells to respond to extracellular environmental stimuli requires the appropriate machinery (both at the membrane and within the cell) to initiate a physiologically relevant response.
Integral components of this machinery are transmembrane receptors that are comprised of several functional domains, including those for ligand binding, transmembrane signaling, and ligand and receptor internalization and recycling (Goldstein et al. 1985). Understanding the molecular interactions involved in the physiological response requires not only an elucidation of the primary structural features and (predicted) functional domains of such molecules, but also of the interaction of such domains in the generation of the appropriate cellular response.
Ligand-activated Tyrosine Phosphokinases: The Insulin Receptor
The response of cells to the polypeptide hormone insulin, is initiated by the binding of insulin to its...
-
↵§ Present address: Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Health Science Center, Dallas, Texas 75235-9050.
-
↵** Present address: 17, rue du Fer-a-Moulin, 75005 Paris, France.
-
↵†† Present address: Laboratoire de Physiologie de la Lactation, INRA CNRZ, 78350 Jouy en Josas, France.
