EXPERIMENTAL STUDIES ON THE FUNCTION OF THE ADRENAL CORTEX
This extract was created in the absence of an abstract.
Excerpt
Few investigators have studied adrenal insufficiency without commenting on the hemoconcentration which becomes so apparent as symptoms progress. The fact that blood concentration occurs in insufficiency has long been known, but for the most part it has been regarded as but one of many abnormal changes which appear, and has generally been considered as a terminal event and not as a primary and initiating factor in inducing symptoms.
In a series of publications (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) the writer and co-workers have insisted that the dehydration and shock symptoms exhibited by the dog in adrenal insufficiency are due chiefly to a profound disturbance in the internal distribution of body water and certain electrolytes. The fluids shift from the blood stream and other extracellular spaces into the tissue cells and are immobilized. The intracellular compartments of the body take up unusual quantities of fluid at...
