The Biology of Lymphocytic Choriomeningitis Infection: Virus-induced Immune Disease
This extract was created in the absence of an abstract.
Excerpt
Lymphocytic choriomeningitis, or LCM, is a naturally occurring virus disease of mice, from which the infection is occasionally transmitted to man. The virus has been known for nearly 30 years, since its first isolation by Armstrong and Lillie in 1934. The human disease varies in severity; it usually occurs as a mild respiratory infection which is sometimes followed by severe meningitis which can be prolonged and debilitating, occasionally fatal (Farmer and Janeway, 1942). Inoculation of the laboratory mouse with LCM virus causes a severe disease which is usually fatal, but natural infection of house mice and some laboratory mouse colonies takes the form of an inapparent latent infection. This paper concerns the results of a 5-year study of experimental murine LCM and the development of new concepts of the pathogenesis of animal virus disease. These concepts relate virus infection not only to immunological tolerance but also to several forms of...
