The Application of Autoradiography to the Study of DNA Viruses

  1. John Cairns
  1. Department of Microbiology, The John Curtin School of Medical Research, Australian National University, Canberra

This extract was created in the absence of an abstract.

Excerpt

INTRODUCTION

It is a truism that for most details one's concept of the process of virus infection is based on one's mental image of the objects involved. For example, the creation of a pool of replicating DNA, and the actions and interactions of the objects within this pool, are thought of in terms of physical entities conjured up more or less precisely according to one's needs, knowledge and inclination. Indeed, it is almost impossible to discuss genetic recombination without having recourse to imagery at some stage. And as this imagery becomes of necessity more detailed, so it also becomes more precarious.

Many of the subjects of this imagery are theoretically within the reach of autoradiography, so there is no need to justify any review of the application of autoradiography to virus research. However, in a symposium on Animal Virus Multiplication, there is some need to justify taking nearly all one's...

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